What is the Difference Between Kyzatrex® and Enclomiphene?

Published: 2025-08-19

Updated: 2025-08-19

5 mins

Testosterone replacement therapy (TRT) is a treatment option for men with health conditions like hypogonadism, who may be experiencing low testosterone levels. Hypogonadism often shows up as a weak sex drive (low libido) or erectile dysfunction.

TRT can help address symptoms like fatigue, mood swings and improve overall well-being by enhancing hormonal health.

While Kyzatrex® and enclomiphene are both used to treat conditions where low testosterone may occur, there are slight differences in how they work. Kyzatrex® is an oral testosterone replacement option, while enclomiphene is an oral medication that increases the body’s natural testosterone production.

In addition to testosterone replacement, a healthcare provider may develop a treatment plan with medication for preexisting health conditions to help you feel more like yourself. Your treatment plan may be a combination of testosterone replacement, dietary adjustments, and increased physical activity.

What is Kyzatrex®?

Kyzatrex® (oral testosterone undecanoate) is an FDA-approved prescription medication used to treat men with hypogonadism. It’s a form of testosterone replacement therapy (TRT) that delivers testosterone directly into your body.

Dosages vary from 100 to 200 mg (milligrams). A healthcare provider may slightly adjust your dosage based on how your body responds to the treatment.

Common Side Effects of Kyzatrex 

Common side effects of Kyzatrex include the following:

• High blood pressure

• Liver complications

• Trouble sleeping

Side effects of Kyzatrex and enclomiphene tend to overlap in some instances.

Make sure to let a healthcare provider know if you are taking other medications. Kyzatrex may negatively interact with corticosteroids, anticoagulants, and insulin.

What is Enclomiphene?

Enclomiphene, also known by the brand name Androxal®, is a selective estrogen receptor modulator (SERM). This type of medication treats secondary male hypogonadism by improving natural testosterone production in the testes. Enclomiphene improves testosterone production by altering luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels in the brain. Enclomiphene also targets estrogen receptors in the hypothalamus.

It’s often used in men who want to maintain fertility. Unlike traditional TRT, health experts have found that enclomiphene doesn’t suppress sperm production.

Some studies also suggest enclomiphene may be more effective than traditional TRT in raising testosterone levels in men with obesity.

Typically, a healthcare provider may recommend a dosage of around 25 mg for three to five days a week. 

Common Side Effects of Enclomiphene

You may experience hot flashes and mood swings while taking enclomiphene. Some men may also experience skin changes like worsening acne while taking enclomiphene.

For some men, this medication may negatively interact with blood thinners and certain herbal supplements.

Main Differences Between Kyzatrex and Enclomiphene

It may take a couple of weeks before you see the effects of either Kyzatrex or enclomiphene because our body needs time to adjust.

Unlike Kyzatrex, enclomiphene is not FDA-approved for testosterone treatment. Instead of supplying testosterone, enclomiphene works by stimulating the body’s natural hormone production of testosterone in the testes. Because of this, enclomiphene is sometimes used in men with fertility complications.

When it comes to dosing, health experts recommend taking Kyzatrex® twice daily with food. Taking it with meals helps improve absorption through the lymphatic system and ensures more stable testosterone levels.

Enclomiphene may not require food for absorption. Its dosing can vary depending on individual needs, and since it is not FDA-approved for testosterone treatment, prescribing practices may differ among healthcare providers.

While more research is needed, Kyzatrex may be used more often by men over 40 who are looking to increase energy levels throughout the day.

Which Medication is More Effective for Testosterone Replacement?

There’s no foolproof way to determine which medication is more effective. Whether one medication works better than the other is unique for each individual. How effective testosterone replacement is for you depends on preexisting conditions and various lifestyle factors.

With Rex MD, you can learn more about which medication may work best for you.

Alternate Forms of Testosterone Treatment

Alternative TRT options include gels, patches, pellets, and injections of testosterone. Most options for TRT are accessible online.

In some cases, a healthcare provider may recommend talk therapy if your ED or hypogonadism are connected to mental health concerns. 

If you have a history of prostate cancer or heart complications, a healthcare provider may suggest other health measures. Either way, it’s important to explore all of your options. Hormonal health plays a bigger role than many people may realize in ensuring we feel healthy every day.

Where Can I Learn More About Testosterone Replacement Therapy?

It can be difficult for men to open up about their health needs. Kyzatrex and enclomiphene are just a few treatment options to increase testosterone levels in men. Rex MD is here to meet you where you are to enhance your lifestyle.

If you’re interested in more options, Rex MD has you covered. The Rex MD Testosterone Program provides accessible testosterone replacement therapy you can order from the comfort of your home.

Get started today and find a treatment that works for you.