The Side Effects of Sermorelin

June 25, 2024

4 min

The human growth hormone (HGH) – initially recognized for its role in childhood growth regulation – is naturally synthesized by the pituitary gland.

As men age, they may become increasingly susceptible to adult-onset growth hormone deficiency (AGHD). This makes older men prone to central weight gain, fat loss, fatigue, low energy levels, anxiety, and depression.

Sermorelin is a synthetic peptide that mimics the effects of the growth hormone. sermorelin intake promotes pituitary health and function during aging and supports individuals in combating symptoms associated with adult-onset growth hormone deficiency.

Is Sermorelin Safe to Use?

Sermorelin received FDA approval in September 1997 for treating growth hormone deficiency in children with short stature. Research indicates that sermorelin can be well-tolerated with minimal side effects when administered under proper medical supervision and with appropriate dosing.

Sermorelin vs. Other Hormone Therapies

Sermorelin differs from bioidentical hormones like estrogen, progesterone, and testosterone. It’s not an end hormone that directly affects the body's functions. Instead, it acts as a secretagogue, encouraging the body to produce its own hormone.

Health experts explain that sermorelin – being smaller than HGH – can bypass the gastrointestinal tract and maintain its essential components. This makes sermorelin a more convenient option for patients.

Most Common Side Effects

Sermorelin is considered a safer alternative to conventional growth hormone injections. Yet, as with any medication, it can have potential side effects. Typically, these effects are mild and lessen as the body adjusts to the treatment.

The most common side effects include:

• Injection site reactions: The injection itself can cause irritation or inflammation at the site, resulting in pain, redness, and swelling. However, proper injection technique, rotating injection sites, and using a sterile needle can help minimize these reactions.

• Headaches: Growth hormone can affect blood flow and pressure in the brain, causing patients to experience headaches after taking sermorelin due to the hormonal changes induced by the medication. Dehydration or changes in blood sugar levels may also contribute to headaches.

• Dizziness: Sermorelin may cause dizziness as the body adjusts to rapid changes in blood pressure, blood sugar, and hormone levels.

• Nausea: Nausea is a common side effect of many medications, and sermorelin is no exception. It could be due to the direct effects of the hormone on the gastrointestinal tract, or it could be a result of hormonal changes affecting digestion and metabolism.

• Flushing: Flushing, or sudden reddening of the skin, can occur due to increased blood flow near the skin's surface. This may be a direct effect of growth hormone or a secondary response to changes in circulation and blood vessel dilation.

If side effects persist or worsen, seek advice from a healthcare professional on managing the side effects or adjusting the dosage.

Less Common Side Effects

Beyond these common effects, there are less frequent but noteworthy side effects to be aware of, including:

• Joint pain

• Hyperactivity or restlessness

• Sleep disturbances

• Changes in appetite

If these side effects persist, consulting a healthcare professional is recommended for further evaluation and management.

Rare and Severe Side Effects

If you experience any of the following severe side effects, seek medical assistance immediately:

• Severe allergic reactions (anaphylaxis): Anaphylaxis is a potentially life-threatening condition with rapid onset of symptoms such as difficulty breathing, swelling of the throat and tongue, a sudden drop in blood pressure, and hives. 

• Swelling of extremities (edema): Edema, or swelling of the extremities such as the hands, feet, ankles, or legs, can occur as a rare side effect of sermorelin. This swelling may be due to fluid retention caused by changes in hormone levels or vascular changes.

• Carpal tunnel syndrome: This condition involves compression of the median nerve as it travels through the wrist. It can lead to symptoms such as numbness, tingling, weakness, or pain in the hand and fingers. 

• Gynecomastia: Gynecomastia is the development of excess breast gland tissue in males, typically caused by hormonal imbalances. Gynecomastia is a rare side effect of sermorelin. If it occurs, be sure to seek medical evaluation.

Potential long-term risks

Seremolin may have long-term side effects for individuals with underlying conditions. If you have diabetes or cardiovascular issues, you may be at a higher risk of experiencing long-term side effects. You may need closer monitoring throughout the duration of the therapy. Long-term side effects include:

• Risk of diabetes 

• Joint pain and swelling 

• Carpal tunnel syndrome 

• Acromegaly 

• Cardiovascular risks

Can Sermorelin Cause Cancer?

Growth hormone-releasing hormone (GHRH) and its receptors may promote tumor growth. In a study on prostate cancer cells, GHRH increased cell viability and proliferation.

Although there appears to be a link between GHRH and cancer promotion, there isn't definitive scientific proof indicating that sermorelin leads to cancer-related side effects. In short, GHRH can potentially cause cancer progression, but it does not cause cancer.

Factors Influencing Side Effects

Impact of dosage and treatment duration on sermorelin side effects

The prescribed dosage of sermorelin and the duration of treatment play critical roles in determining the likelihood and severity of these side effects. Higher doses or prolonged use may elevate the risk of adverse reactions, highlighting the importance of precise dosing and regular medical supervision.

Underlying conditions and interactions with other medications

Sermorelin’s interaction with other medications could affect the severity of these side effects – particularly in relation to diabetes and cardiovascular issues.

Seremolin may interact with other medications, particularly those used to manage conditions such as diabetes. It's important to inform healthcare providers about all medications being taken to minimize the risk of interactions and potential side effects. 

Some conditions – such as having underactive thyroid – may also affect how sermorelin works in the body. If hypothyroidism is not treated, it can compromise the effectiveness of sermorelin. Thyroid levels should be assessed before starting and during sermorelin therapy to maintain optimal levels.

Lifestyle factors 

Additionally, lifestyle factors such as diet, exercise habits, and alcohol consumption can significantly influence how the body responds to sermorelin. By addressing these factors and collaborating closely with healthcare professionals, you can better manage side effects and achieve optimal outcomes from sermorelin therapy.

How to Manage and Mitigate Side Effects

Discuss existing conditions 

Inform your healthcare provider about any pre-existing medical conditions you have, especially conditions related to hormone regulation or diabetes, as these may influence how sermorelin affects you.

Follow dosage guidelines

It’s important to stick to the prescribed dosage as directed by your healthcare provider. Avoid adjusting the dosage on your own.

Monitor blood sugar levels

Sermorelin can affect insulin sensitivity. If you have diabetes or are at risk of developing it, monitor your blood sugar levels closely and report any abnormalities to your doctor.

Hydrate 

Drinking plenty of water can help alleviate some side effects, like headaches.

Manage injection site reactions

If you experience redness, swelling, or pain at the injection site, applying ice can help reduce discomfort. Rotate injection sites as recommended by your healthcare provider to minimize irritation.

Address sleep disturbances

Some people may experience difficulty sleeping when using sermorelin. Establishing good sleep hygiene practices – such as maintaining a regular sleep schedule and creating a comfortable sleep environment – may help. If sleep disturbances persist, discuss them with your doctor.

Report any persistent issues

If you notice any persistent or severe side effects — such as nausea, vomiting, or allergic reactions (like rash or difficulty breathing) — contact your healthcare provider immediately.

Regular follow-ups

Attend follow-up appointments as scheduled so that your doctor can monitor your response to sermorelin and adjust the treatment if necessary.

Lifestyle modifications

Adopting a healthy lifestyle, including regular exercise and a balanced diet, can support the overall effectiveness of sermorelin therapy and help mitigate side effects.

Rex MD Can Help You Manage the Side Effects of Sermorelin 

Balanced testosterone and GH levels are key factors in men’s health, and fortunately, Rex MD can help. With the Rex MD TestoRx program, you’ll have access to medications like sermorelin.

To find out if the program is right for you, just answer a few questions about your symptoms and medical history. You’ll then be able to schedule a virtual call with the Rex MD care team.

Your provider will order lab work for you to determine if you’re eligible for our treatment options and assist you in managing any side effects.