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Enclomiphene for Men

March 26, 2024
4 mins
Dr. Russell Van Maele

Enclomiphene is a selective estrogen receptor modulator (SERM) that is used in the treatment of infertility in men. It works by stimulating the production of testosterone in the testes, which can help improve sperm production and quality.

It’s a non-steroidal medication that is similar in structure to clomiphene, another SERM commonly used in the treatment of infertility in women.

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What are the Benefits of Enclomiphene for Men?

Enclomiphene has proven beneficial for men with low testosterone levels. This condition – male hypogonadism – affects various aspects of men’s health. Enclomiphene can benefit men with a testosterone deficiency in the following ways.

Improved fertility

Enclomiphene can stimulate the production of testosterone in the testes. By blocking estrogen's negative feedback, enclomiphene effectively increases the production of two hormones that play a role in testosterone production. This then leads to an increase in testosterone production by the Leydig cells in the testes.

Higher levels of testosterone can help improve sperm production (spermatogenesis) and quality, as testosterone is crucial for the development and maturation of spermatozoa.

This can improve fertility in men who have low testosterone levels.

Increased muscle mass

Testosterone plays a crucial role in the development and maintenance of muscle mass in men. It’s an anabolic hormone that promotes protein synthesis in muscle tissues, which is essential for muscle growth and repair.

Testosterone also helps to increase muscle strength and endurance, which can benefit athletic performance and overall physical function.

Enclomiphene – by stimulating the production of testosterone in the testes – can help to increase circulating testosterone levels in men with low testosterone. This increase in testosterone can have a positive impact on muscle mass by promoting muscle protein synthesis, increasing muscle strength and endurance, and enhancing overall physical performance.

Improved libido and sexual function

When testosterone levels are low, it can negatively impact a man's libido and sexual function. Symptoms of low testosterone levels may include reduced sexual desire, erectile dysfunction, decreased arousal, and difficulties achieving or maintaining an erection.

Enclomiphene can increase circulating testosterone levels in men with low testosterone. This increase in testosterone may help to improve libido and sexual function by restoring hormonal balance and addressing the underlying cause of sexual health issues related to low testosterone levels.

Boosted energy and mood

Testosterone is not only important for physical health but also plays a significant role in mental and emotional well-being in men. Low testosterone levels have been linked to symptoms of fatigue, low energy, irritability, mood swings, and even depression. When testosterone levels are inadequate, it can negatively impact a man's overall mood and energy levels.

In boosting testosterone levels, enclomiphene can have a positive effect on men’s mental and emotional well-being.

Potential for weight loss

Testosterone plays a crucial role in regulating metabolism, body composition, and weight management in men. Low testosterone levels have been associated with an increased risk of obesity, higher body fat percentage, and metabolic disturbances. When testosterone levels are insufficient, it can lead to reduced metabolic rate, decreased muscle mass, and an imbalance in fat distribution.

For men with low testosterone levels, enclomiphene therapy may help support weight management efforts and promote a healthier body composition. It is important to note that individual responses to enclomiphene treatment may vary, and weight loss results may be influenced by various factors such as diet, exercise, and lifestyle habits.

Can Women Take Enclomiphene?

Enclomiphene is primarily used in the treatment of infertility in men and is not approved for use in women. However, the related medication clomiphene, is commonly used in women to stimulate ovulation.

Clomiphene is similar in structure to enclomiphene but has mixed estrogen receptor effects, while enclomiphene is a selective estrogen receptor modulator that primarily acts on estrogen receptors in the hypothalamus and pituitary gland.

If a woman is experiencing infertility and is considering treatment with enclomiphene or a similar medication, she should consult with a fertility specialist or healthcare provider for a proper evaluation and recommendation regarding the most appropriate treatment options.

Where Can You Get Enclomiphene?

Enclomiphene is a prescription medication and can only be obtained with a prescription from a healthcare provider. It’s not typically available over-the-counter or through online pharmacies without a prescription.

With the Rex MD TestoRx program, you’ll have access to quality care from a team of licensed clinicians and testosterone solutions, if appropriate.

To find out if the program is right for you, just answer some about your symptoms and medical history. Your provider will order lab work for you to help determine if you’re eligible for testosterone injections or another treatment option.

Then, you’ll be able to schedule a virtual call with the Rex MD care team to further discuss your results, eligibility, and which treatment option would be most suitable for you, if any.

Get started today.

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