Everything You Need to Know About Testosterone Enanthate

March 30, 2024

4 mins

Testosterone enanthate is a synthetic form of testosterone, the primary male sex hormone. It’s administered via injection and gradually released into the bloodstream over time. 

As a crucial hormone, testosterone enanthate plays pivotal roles in the development and maintenance of male sexual characteristics, including the growth of facial and body hair, deepening of the voice, and maturation of the male reproductive system. 

Testosterone enanthate is involved in various physiological processes throughout the body, such as muscle growth, bone density regulation, and red blood cell production. Medically, it is prescribed to treat conditions associated with low testosterone levels – such as hypogonadism – aiming to alleviate symptoms and improve overall well-being. 

How Does Testosterone Enanthate Work?

The medication works by supplementing or replacing the body's natural production of testosterone. Once injected into the body, testosterone enanthate is slowly released into the bloodstream over a period of several days.

Testosterone enanthate is often used to treat conditions associated with low testosterone levels, such as hypogonadism. By providing exogenous (externally sourced) testosterone, testosterone enanthate helps restore testosterone levels to within the normal range, alleviating symptoms associated with testosterone deficiency and promoting overall well-being.

How Do You Take Testosterone Enanthate?

Testosterone enanthate is typically administered via intramuscular injection, commonly into the gluteal muscle. The dosage and frequency of administration depend on various factors, including the individual's age, medical condition, and response to treatment. In adults with testosterone deficiency, a typical starting dose might be around 50 to 100 milligrams injected every seven to 10 days, although dosages can vary significantly based on individual needs.

Prior to administration, healthcare providers should thoroughly educate patients on proper injection technique and disposal of needles and syringes. Additionally, patients should receive regular monitoring to assess their response to treatment and adjust the dosage as needed to maintain testosterone levels within the normal range.

It's crucial to follow the prescribed dosage and administration schedule precisely to maximize the benefits of testosterone therapy while minimizing the risk of adverse effects. Deviating from the recommended dosage or administration frequency can lead to fluctuations in testosterone levels and potentially compromise treatment efficacy. 

What are the Side Effects of Testosterone Enanthate?

Like any medication, testosterone enanthate can have potential side effects. Some common side effects of testosterone enanthate include:

• Injection site reactions: Pain, redness, or irritation at the injection site is common.

• Fluid retention: Testosterone can cause the body to retain water, leading to swelling in the hands, ankles, or feet.

• Acne: Some individuals may experience an increase in acne, especially on the face, chest, or back.

• Increased libido: While this might not necessarily be considered a negative side effect, increased libido or sexual desire can occur with testosterone therapy.

• Hair growth: Testosterone can stimulate hair growth, including on the face and body. This might be desirable for some, but it can be unwanted in others.

• Hair loss: Curiously, testosterone can also contribute to male pattern baldness in those who are genetically predisposed.

• Changes in mood: Some people may experience mood swings, irritability, or aggression.

• Sleep apnea: Testosterone therapy can worsen sleep apnea or other breathing problems, particularly in individuals who already have these conditions.

• Cholesterol imbalance: Testosterone can affect cholesterol levels, potentially increasing LDL cholesterol (the "bad" cholesterol) while decreasing HDL cholesterol (the "good" cholesterol).

• Suppression of natural testosterone production: Long-term use of exogenous testosterone can suppress the body's natural production of testosterone, leading to dependence on external supplementation.

• Cardiovascular issues: There is some evidence suggesting that testosterone therapy might increase the risk of cardiovascular problems, including heart attack and stroke, particularly in older men with pre-existing heart conditions.

It's important to note that not everyone will experience these side effects, and some individuals may experience different or additional side effects not listed here. Additionally, the severity of side effects can vary from person to person. 

If you're considering testosterone therapy, it's crucial to discuss the potential risks and benefits with a healthcare provider who can provide personalized guidance based on your medical history and individual circumstances.

Does Testosterone Enanthate Interact with Any Other Drugs?

Yes, testosterone enanthate may interact with other drugs, potentially altering their effects or increasing the risk of side effects. 

For instance, medications such as corticosteroids, anticoagulants, and insulin may have their effectiveness modified when taken alongside testosterone enanthate. 

Additionally, drugs that affect liver function – such as certain antifungal medications and barbiturates – could impact the metabolism of testosterone enanthate. 

Concurrent use of testosterone enanthate with medications that lower blood sugar levels or increase the risk of fluid retention, such as diuretics, could lead to exacerbated effects. 

Testosterone enanthate may interact with certain medications used to treat prostate issues, potentially worsening symptoms or complicating treatment. 

It's crucial for individuals undergoing testosterone therapy to inform their healthcare provider about all medications they are taking to minimize the risk of adverse interactions and ensure safe and effective treatment.

Who Shouldn’t Take Testosterone Enanthate?

Testosterone enanthate may not be suitable for everyone, and there are certain individuals who should avoid or use caution when taking this medication. 

People who have or have had prostate cancer or breast cancer should not take testosterone enanthate, as it can potentially stimulate the growth of these types of tumors. 

Additionally, while women may be prescribed testosterone, women who are pregnant, breastfeeding, or planning to become pregnant should avoid testosterone enanthate, as it can cause harm to the fetus or nursing infant.

People with severe liver disease or severe kidney disease should use testosterone enanthate with caution, as it may exacerbate these conditions or lead to complications. 

Those with cardiovascular disease, including heart failure, coronary artery disease, or a history of stroke, should also use testosterone enanthate with caution, as testosterone therapy may increase the risk of cardiovascular events.

It's essential to discuss your medical history and any potential risk factors with your healthcare provider before starting testosterone enanthate therapy to ensure that it is safe and appropriate for you.

Your healthcare provider can assess your individual risk factors and provide guidance on the best treatment options for your specific situation. Additionally, regular monitoring and follow-up with your healthcare provider are essential to ensure the safety and effectiveness of testosterone enanthate therapy.

How Much Does Testosterone Enanthate Cost?

Testosterone injections – including testosterone enanthate – are often costly. 

Testosterone Enanthate, available as a generic medication, typically comes in a 10ml vial, with prices ranging from $50 to $150 per vial. While generic versions may be more affordable compared to brand-name alternatives, the overall expense of testosterone therapy can still be considerable, especially when considering additional costs such as doctor's visits, lab tests, and administration supplies. 

This price range can fluctuate based on factors such as geographic location, pharmacy discounts, and insurance coverage. Consequently, those seeking testosterone therapy should be prepared for potential financial commitments and explore options for cost mitigation, such as insurance coverage or assistance programs, to ensure access to necessary treatment while managing expenses effectively.

Are There Any Alternative Treatments?

While all testosterone injections aim to restore testosterone levels, the medications themselves can be slightly different. Other testosterone injections include:

• Testosterone undecanoate: an intramuscular injection given into the gluteal muscle by a healthcare provider. The brand name option for testosterone undecanoate is called Aveed. Its notable distinction from other testosterone injections lies in its dosage. The recommended dose is 750 mg, with a follow-up injection scheduled after four weeks. Subsequent doses can be administered every 10 weeks, amounting to approximately five shots per year.

• Testosterone cypionate: Also marketed under the brand name Depo-Testosterone, testosterone cypionate is a prevalent form of injectable testosterone. Administered intramuscularly into the buttocks every two to four weeks, this injection can be self-administered at home or administered by a healthcare provider. The recommended dosage of testosterone cypionate varies depending on factors such as age, individual response to the medication, and the presence of potential side effects. Dosages typically fall within the range of 50 mg to 400 mg.

• Testosterone propionate: another alternative for testosterone injections. Despite its lower cost compared to other injection options, testosterone propionate is less favored due to its dosage regimen. Propionate requires more frequent injections, potentially up to daily, as it releases testosterone gradually, aiding in maintaining stable testosterone levels.

Other alternatives to testosterone injections include topical gels. Testosterone gel is a convenient and non-invasive mode of administration compared to other forms of TRT. This is because of its topical application in easy-to-reach areas of the body. 

The most popular testosterone replacement gel is called AndroGel® 1.62%. It’s a controlled substance available by prescription only for men. 1.62% refers to the strength of testosterone in each dose (40.5 mg of testosterone).

While testosterone replacement therapies such as the ones discussed are effective in treating hypogonadism, other medications exist that do just the same. While medications like testosterone cypionate use synthetic testosterone to restore T levels, a medication like clomiphene (Clomid) works by stimulating the production of testosterone and blocking the production of estrogen.

Clomiphene is typically prescribed off-label for men with infertility issues related to low testosterone levels or abnormal sperm parameters. It is usually taken orally in pill form for a specified duration under the supervision of a healthcare provider. 

How Can Rex MD Help?

Balanced testosterone levels are a key factor in men’s health, and fortunately, Rex MD has got what you need to boost your testosterone. 

With the Rex MD TestoRx program, you’ll have access to quality care and testosterone medications that can help you feel like yourself again. 

To find out if the program is right for you, just answer some questions about your symptoms and medical history. Your provider will order lab work for you to help determine if you’re eligible for TRT or another testosterone solution available through the program.

Then, you’ll be able to schedule a virtual call with the Rex MD care team to further discuss your results, eligibility, and which treatment option would be most suitable for you, if any.

Get started today.