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Get the Rest You Deserve...

Enjoy Up To 7 Hours
Of Great Sleep!

  • FDA-approved and
    non-addictive
    medications

  • Fall asleep faster and
    stay
    asleep longer

  • Wake up refreshed for a
    positive
    and productive day

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Rex MD® offers FDA-approved prescription medications that can help you fall asleep faster and stay asleep longer.

Important safety Info

Rex MD® offers FDA-approved prescription medications that can help you fall asleep faster and stay asleep longer.

Important safety Info

Best Sleep Ever with Rex MD

Say goodnight to tossing and turning

Stay Asleep Longer
Wake Up Refreshed
Backed By Science
FDA-Approved
No Doctors Visits
Medical Support

Get back to sleep with Rex MD®

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    Doctor Prescribed
    Sleep Treatments

  • How it works

    As the leading online healthcare provider, Rex MD® has the ability to prescribe safe, nonaddictive prescription sleep medications that can help you finally get to bed at night so you can conquer the day.

    Feel positive & productive

    Life is better when you get the sleep you need.

    • FDA-approved treatments available
    • Wake up refreshed and ready
    • Delivered Free direct to your door
    • 100% Online with no office visit
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    Step 1

    Obtain your prescription

    Fill out our free online consultation and get your
    sleep prescription from a US-licensed physician.

    Step 2

    Receive your medication

    Your prescription sleep treatment will be sent in discreet
    packaging, with free two-day delivery.

    Step 3

    Enjoy longer-lasting sleep

    30 minutes before bedtime, take your medication and
    perform your nightly routine and enjoy up to seven hours
    of uninterrupted sleep.

    Step 4

    Get ongoing support

    Have a question or concern? Message our patient care
    team any time. We’re here to help.

    One third of U.S. adults report that they usually get less
    than the recommended amount of sleep.
    Not getting
    enough sleep is linked with many chronic diseases and
    conditions such as type 2 diabetes, heart disease, obesity,
    and depression. Getting enough sleep is not a luxury—it is
    something you need for good health.

    As the leading online healthcare provider, we take the
    hassle, expense, and confusion out of treating sleep
    deprivation. Get started now!

    Feel positive & productive

    Life is better when you get the sleep you need.

    • FDA-approved treatments available
    • Wake up refreshed and ready
    • Delivered Free direct to your door
    • 100% Online with no office visit
    Start My Free Online Visit
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    Treat Insomnia

    Ramelteon to fall asleep faster

    Ramelteon is a sedative shown to help patients drift off faster for a longer, more restful night of sleep. It mimics the effects of natural sleep hormones to help you feel tired and ready for bed.

    • Reduces the amount of time it takes to fall asleep
    • FDA-approved for the treatment of insomnia
    • Approximately 10X stronger than melatonin
    Sleep Great

    Doxepin to stay asleep longer

    Doxepin is a tricyclic antidepressant used to help patients with sleep-onset insomnia sleep soundly. It controls your circadian rhythm, the process that regulates your sleep-wake cycle.

    • Reduces the frequency waking up at night
    • Helps extend sleep duration for a more restful night
    • FDA-approved for the treatment of insomnia
    Wake Up Refreshed

    Trazodone to sleep all night

    Trazodone is a serotonin modulator that helps people fall asleep and stay asleep through the night. Trazodone is an effective prescription treatment used off-label for insomnia.

    • Supports deeper sleep with fewer interruptions
    • Safe for both short-term and long-term insomnia
    • Promotes improved mental balance and wellbeing
    You’re in great hands with Rex MD.

    It’s not just about falling asleep,
    it’s about staying asleep.

    It’s not just about falling asleep, it’s about staying asleep.

    Frequently Asked Questions

    Say goodnight to tossing and turning

    • What is insomnia?

      Insomnia is a common sleep disorder. If you have it, you may have trouble falling asleep, staying asleep, or both. Insomnia can negatively impact your energy levels, mood, health and overall quality of life.

    • What medications does Rex MD® offer for sleep?

      Rex MD® offers rozerem (generic Ramelteon), doxepin (generic Silenor), and trazodone (generic Desyrel).

      Rozerem is a melatonin receptor agonist used to help patients who have sleep-onset insomnia (difficulty falling asleep) fall asleep more quickly. It works similarly to melatonin, a natural substance in the brain that is needed for sleep.

      Doxepin is a hypnotic (sleep) medicine that is used to treat people who have trouble staying asleep. Doxepin has not been shown to cause physical dependence or withdrawal symptoms.

      Trazodone is a serotonin modulator that helps people fall asleep and stay asleep through the night. It blocks histamines known to cause wakefulness, making you feel drowsy and ready for sleep.

    • Do I need to see a medical provider in person?

      No! Rex MD® is a telehealth company. We offer a convenient, easy-to-use website and app for patients to access licensed medical providers from across their smartphone or computer screen. Patients can get a diagnosis, prescription initiation or refill, lab order, and more — all without leaving home.

    • What information do I need to provide?

      In order to obtain prescription sleep medication, you must complete an online doctor visit that includes a simple questionnaire. During your online doctor visit, please disclose if you suffer from any of the following issues:

      • 1. A history of depression, mental illness, or suicidal thoughts
      • 2. Severe sleep apnea
      • 3. Kidney or liver problems
      • 4. A history of drug or alcohol abuse or addiction
      • 5. A history of glaucoma or urinary retention
      • 6. Any other medical conditions
    • Are sleep medications from Rex MD® addictive?

      No. While controlled substances like Ambien pose a high risk for dependency, the medications we prescribe are nonaddictive and safe to use on a regular basis.

    • Do I need insurance?

      With Rex MD®, you don’t need insurance to access quality care. Thanks to our unique care model, getting treatment is both accessible and affordable.

    • “This was my first time using telemedicine and I have to say it was simple and discreet. I would recommend this process to anyone.

      Joe B.

      Verified Patient

    • “Everything was exactly as it was explained. It couldn’t be easier.

      Gary B.

      Verified Patient

    • “Everything was perfect. My prescription showed up on time the doctor was easy to talk to - I couldn’t be happier with the product.

      Scott S.

      Verified Patient

    • "Love your service and product. Changed everything for the better. THANK YOU !!!"

      John B.

      Verified Patient

    • "Great dealing with you guys!!!"

      Chris G.

      Verified Patient

    • “You are doing an excellent job. Keep up the good work.

      Jeff W.

      Verified Patient

    • "The experience was smooth and fantastic."

      Neal B.

      Verified Patient

    • "The service was great and the price was affordable."

      Billy I.

      Verified Patient

    • You provide an excellent product, great customer service and fast delivery. Thank you and keep up the good work.”

      James M.

      Verified Patient

    • "Everything was done in a timely manner. Totally Awesome."

      Dale H.

      Verified Patient

    • "Was actually easy for a non computer savvy old man."

      Dave P.

      Verified Patient

    • "I've attempted to use two other sites and they made it exceptionally difficult and drawn out. Your system was quick and efficient."

      Michael M.

      Verified Patient

    • “I was skeptical at first. After a painless questionnaire everything worked out great."

      Dan D.

      Verified Patient

    • "I can’t think of anything else that could be better, this system is perfect."

      Ben T.

      Verified Patient

    • "I think a lot of customers will be very satisfied like I am."

      Chris W.

      Verified Patient

    • "Keep making your customer service awesome for all customers."

      Alan S.

      Verified Patient

    • “A wonderful addition to my sleep regimen. I wake up feeling well rested and energetic.

      Frank H.

      Verified Patient

    • “Going to sleep a little faster and sleeping about 2 hours longer.

      Pierre L.

      Verified Patient

    • I slept like a baby, very much helpful. Thank you.”

      Bernie F.

      Verified Patient

    • “Helps me sleep longer.

      Andrew F.

      Verified Patient

    Genuine medication.
    No hidden fees.
    Fast, free delivery.

    Genuine medication.
    No hidden fees.
    Fast, free delivery.

    If prescribed, your medication will be rushed to your door
    with free two-day delivery, directly from the pharmacy.

    If prescribed, your medication
    will be rushed to your door with free two day
    delivery, directly from the pharmacy.

    Don’t waste another precious night tossing and turning. If you have trouble falling asleep, staying asleep, or feeling rested when you wake up, Rex MD® can help.

    Start My Free Online Visit

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    Important safety Info

    Don’t waste another precious night tossing and turning. If you have trouble falling asleep, staying asleep, or feeling rested when you wake up, Rex MD® can help.

    Special: Save 50% Off + Free Rush Shipping

    Frequently Asked Questions

    Say goodnight to tossing and turning

    • What is insomnia?

      Insomnia is a common sleep disorder. If you have it, you may have trouble falling asleep, staying asleep, or both. Insomnia can negatively impact your energy levels, mood, health and overall quality of life.

    • What medications does Rex MD® offer for sleep?

      Rex MD® offers rozerem (generic Ramelteon), doxepin (generic Silenor), and trazodone (generic Desyrel).

      Rozerem is a melatonin receptor agonist used to help patients who have sleep-onset insomnia (difficulty falling asleep) fall asleep more quickly. It works similarly to melatonin, a natural substance in the brain that is needed for sleep.

      Doxepin is a hypnotic (sleep) medicine that is used to treat people who have trouble staying asleep. Doxepin has not been shown to cause physical dependence or withdrawal symptoms.

      Trazodone is a serotonin modulator that helps people fall asleep and stay asleep through the night. It blocks histamines known to cause wakefulness, making you feel drowsy and ready for sleep.

    • Do I need to see a medical provider in person?

      No! Rex MD® is a telehealth company. We offer a convenient, easy-to-use website and app for patients to access licensed medical providers from across their smartphone or computer screen. Patients can get a diagnosis, prescription initiation or refill, lab order, and more — all without leaving home.

    • What information do I need to provide?

      In order to obtain prescription sleep medication, you must complete an online doctor visit that includes a simple questionnaire. During your online doctor visit, please disclose if you suffer from any of the following issues:

      • 1. A history of depression, mental illness, or suicidal thoughts
      • 2. Severe sleep apnea
      • 3. Kidney or liver problems
      • 4. A history of drug or alcohol abuse or addiction
      • 5. A history of glaucoma or urinary retention
      • 6. Any other medical conditions
    • Are sleep medications from Rex MD® addictive?

      No. While controlled substances like Ambien pose a high risk for dependency, the medications we prescribe are nonaddictive and safe to use on a regular basis.

    • Do I need insurance?

      With Rex MD®, you don’t need insurance to access quality care. Thanks to our unique care model, getting treatment is both accessible and affordable.

    Take the first step towards
    more compliments, looking great in photos, baggy
    clothes that no longer fit... and a healthier, happier,
    more confident you!

    Start My Free Online Visit
    Special: Save 50% Off + Free Rush Shipping

    Important Safety Information

    Insomnia & Sleep
    Last Updated: May 16, 2024
    1. Ramelteon
    2. Trazodone
    3. Doxepin
     

    Call your doctor if your insomnia worsens or is not better within 7 to 10 days. This may mean that there is another condition causing your sleep problem.

    Be sure that you are able to devote 7 to 8 hours to sleep before being active again. Never take this medicine during your normal waking hours, unless you have at least 7 to 8 hours to dedicate to sleeping.

    Ramelteon should be taken within 30 minutes of bedtime. Do not take with alcohol or with other medicines that can make you sleepy. You should not drive or operate machinery at night after taking Ramelteon. Until you know how you will react to Ramelteon, you should be careful in performing such activities during the day following taking Ramelteon. Before you take Ramelteon, tell your doctor if you have a history of depression, mental illness or suicidal thoughts. You should call your doctor right away if after taking Ramelteon you walk, drive, eat or engage in other activities while asleep. Drowsiness is the most common adverse event observed in clinical trials. For more information, please see the complete Prescribing Information, including the Medication Guide.

    What should I tell my healthcare provider before taking Ramelteon?

    Before you take Ramelteon, tell your healthcare provider if you:

    • Have a history of depression, mental illness, or suicidal thoughts
    • Have severe sleep apnea
    • Have kidney or liver problems
    • Have a history of drug or alcohol abuse or addiction
    • Have a history of glaucoma or urinary retention
    • Have any other medical conditions

    Tell your doctor about all of the medicines you take including prescription and nonprescription medicines, vitamins and herbal supplements.

    Ramelteon and other medicines may affect each other causing side effects. Ramelteon may affect the way other medicines work, and other medicines may affects how Ramelteon works. Especially tell your healthcare provider if you take: Luvox (fluvoxamine).

    Who should not take Ramelteon?

    You should not use Ramelteon if you are allergic to it, or if:

    • You have severe liver disease; or
    • You also take fluvoxamine.

    Ask your doctor or pharmacist if you are not sure if your medicine is one that is listed above.

    Know the medicines you take. Keep a list of your medicines with you to show your doctor and pharmacist each time you get a new medicine.

    Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide.

    Do not use Ramelteon for a condition for which it was not prescribed. Do not share Ramelteon with other people, even if you think they have the same symptoms that you have. It may harm them.

    INDICATIONS

    Ramelteon is a sedative, also called a hypnotic. It works by affecting certain substances in your body that help regulate your "sleep-wake cycle."

    Ramelteon is used to treat insomnia that is associated with having trouble falling asleep.

    Dosing In Adults

    The recommended dose of Ramelteon is 8 mg taken within 30 minutes of going to bed. It is recommended that Ramelteon not be taken with or immediately after a high-fat meal. The total Ramelteon dose should not exceed 8 mg per day.

    Dosing In The Elderly

    The recommended starting dose of Ramelteon in elderly patients (≥ 65 years old) is 8 mg once daily.

    Administration

    Ramelteon should be taken within 30 minutes of bedtime.

    To minimize the potential for next day effects, Ramelteon should not be taken within 3 hours of a meal.

    The total Ramelteon dose should not exceed 8 mg per day.

    How should I take Ramelteon?

    • Take Ramelteon exactly as your healthcare provider tells you to take it.
    • Your healthcare provider will tell you how much Ramelteon to take and when to take them.
    • Your healthcare provider may change your dose if needed.
    • Take Ramelteon within 30 minutes of bedtime. After taking Ramelteon, you should confine your activities to those necessary to prepare for bed.
    • Do not take Ramelteon within 3 hours of a meal. Ramelteon may not work as well, or may make you sleepy the next day if taken with or right after a meal.
    • Do not take Ramelteon unless you are able to get a full night of sleep before you must be active again.

    Call your healthcare provider if your sleep problems get worse or do not get better within 7 to 10 days. This may mean that there is another condition causing your sleep problem.

    If you take too much Ramelteon, call your doctor or get medical help right away.

    What should I avoid while taking Ramelteon?

    You should not drink alcohol while taking Ramelteon. Alcohol can increase your chances of getting serious side effects with Ramelteon. You should not drive, operate heavy machinery, or do other dangerous activities after Ramelteon. You may still feel drowsy the next day after taking Ramelteon. Do not drive or do other dangerous activities after taking Ramelteon until you feel fully awake.

    What is the most important information I should know about Ramelteon?

    The most common side effect of Ramelteon is drowsiness or tiredness.

    Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

    These are not all the possible side effects of Ramelteon. For more information ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

    How should I store Ramelteon?

    Store Ramelteon between 68° and 77°F (20° to 25°C).

    Keep Ramelteon in a tightly closed container, and away from light. Safely throw away medicine that is out of date or no longer needed.

    Keep Ramelteon and all medicines out of the reach of children.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

     

    Read the Medication Guide that comes with trazodone hydrochloride tablets before you start taking it and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment. Talk to your healthcare provider or pharmacist if there is something you do not understand or you want to learn about trazodone hydrochloride tablets.

    What is the most important information I should know about trazodone hydrochloride tablets?

    Antidepressant medicines, depression or other serious mental illnesses, and suicidal thoughts or actions: Talk to your healthcare provider about:

    • All risks and benefits of treatment with antidepressant medicines
    • All treatment choices for depression or other serious mental illnesses

    1. Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment.

    2. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Some people may have a higher risk of having suicidal thoughts or actions. These include people who have or have a family history of bipolar illness (also called manic- depressive illness) or suicidal thoughts or actions.

    3. How can I watch for and try to prevent suicidal thoughts and actions?

    Pay close attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed. Call your healthcare provider right away to report new or sudden changes in mood, behavior, thoughts or feelings. Keep all follow-up visits with your healthcare provider as scheduled. Call your healthcare provider between visits as needed, especially if you are worried about symptoms.

    Call a healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you:

    • Thoughts about suicide or dying
    • Attempts to commit suicide
    • New or worse depression
    • New or worse anxiety
    • Feeling very agitated or restless
    • Panic attacks
    • Trouble sleeping (insomnia)
    • New or worse irritability
    • Acting aggressive, being angry or violent
    • Acting on dangerous impulses
    • An extreme increase in activity and talking (mania)
    • Other unusual changes in behavior or mood

    4. Visual problems: eye pain changes in vision swelling or redness in or around the eye

    • eye pain
    • changes in vision
    • swelling or redness in or around the eye

    Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.

    5. What else do I need to know about antidepressant medicines?

    Never stop an antidepressant medicine without first talking to a healthcare provider.

    Stopping an antidepressant medicine suddenly can cause other symptoms.

    Antidepressants are medicines used to treat depression and other illnesses. It is important to discuss all the risks of treating depression and also the risks of not treating it. You should discuss all treatment choices with your healthcare provider, not just the use of antidepressants.

    Antidepressant medicines have other side effects. Talk to your healthcare provider about the side effects of your medicines.

    Antidepressant medicines can interact with other medicines. Know all of the medicines that you take. Keep a list of all medicines to show your healthcare provider. Do not start new medicines without first checking with your healthcare provider.

    Trazodone hydrochloride tablets are not approved for use in children. Talk to your healthcare provider for more information

    What are trazodone hydrochloride tablets?

    Trazodone hydrochloride tablets are a prescription medicine used to treat major depressive disorder in adults.

    What should I tell my healthcare provider before taking trazodone hydrochloride tablets?

    Before you take trazodone hydrochloride tablets tell your healthcare provider if you:

    • have heart problems, including QT prolongation or a family history of it
    • have ever had a heart attack
    • have bipolar disorder
    • have liver or kidney problems
    • have other serious medical conditions
    • are pregnant or plan to become pregnant. Trazodone hydrochloride tablets may harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant.
    • are breastfeeding or plan to breastfeed. It is not known if trazodone hydrochloride tablets into your breast milk. You and your healthcare provider should decide if you will take trazodone hydrochloride or breastfeed.
    • have taken a Monoamine Oxidase Inhibitor (MAOI) or if you have stopped taking an MAOI in the last 2 weeks.

    Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

    Using trazodone hydrochloride tablets with certain other medicines can affect each other causing serious side effects.

    Know the medicines you take. Keep a list of them and show it to your healthcare provider and pharmacist when you get a new medicine.

    How should I take trazodone hydrochloride tablets?

    • Take trazodone hydrochloride tablets exactly as your healthcare provider tells you.
    • If you feel drowsy after taking trazodone hydrochloride tablets, talk to your healthcare provider. Your healthcare provider may change your dose or the time of day you take your trazodone hydrochloride tablets.
    • Do not stop taking trazodone hydrochloride tablets without talking to your healthcare provider.
    • Trazodone hydrochloride tablets should be swallowed whole or broken in half along the score line. Do not chew or crush trazodone hydrochloride tablets. Tell your healthcare provider if you cannot swallow trazodone either whole or as a half tablet. If you take too much trazodone hydrochloride, call your doctor or go to the nearest emergency room right away.

    What should I avoid while taking trazodone hydrochloride tablets?

    • Do not drive, operate heavy machinery, or do other dangerous activities until you know how trazodone hydrochloride tablets affect you. Trazodone hydrochloride tablets can slow your thinking and motor skills.
    • Do not drink alcohol or take other medicines that make you sleepy or dizzy while taking trazodone hydrochloride tablets until you talk with your healthcare provider. Trazodone hydrochloride tablets may make your sleepiness or dizziness worse if you take it with alcohol or other medicines that cause sleepiness or dizziness.

    What are the possible side effects of trazodone hydrochloride tablets?

    Trazodone hydrochloride tablets can cause serious side effects or death. See “What is the most important information I should know about trazodone hydrochloride tablets?”

    Serious side effects include:

    • Serotonin syndrome. Symptoms of serotonin syndrome include: agitation, hallucinations, problems with coordination, fast heartbeat, tight muscles, trouble walking, nausea, vomiting, diarrhea.
    • Feeling high or in a very good mood, then becoming irritable, or having too much energy, feeling like you have to keep talking or do not sleep (mania).
    • Irregular or fast heartbeat or faint (QT prolongation).
    • Low blood pressure. You feel dizzy or faint when you change positions (go from sitting to standing).
    • Unusual bruising or bleeding.
    • Erection lasting for more than 6 hours (priapism).
    • Low sodium in your blood (hyponatremia). Symptoms of hyponatremia include: headache, feeling weak, feeling confused, trouble concentrating, memory problems and feeling unsteady when you walk.
    • Withdrawal symptoms. Symptoms of withdrawal can include anxiety, agitation, and sleep problems. Do not stop taking trazodone hydrochloride tablets without talking to your healthcare provider.

    Get medical help right away, if you have any of the symptoms listed above.

    The most common side effects of trazodone hydrochloride tablets include:

    • Sleepiness
    • Dizziness
    • Constipation
    • Blurry vision

    Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

    These are not all the possible side effects of trazodone hydrochloride tablets. For more information, ask your healthcare provider or pharmacist .

    Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

     

    Call your doctor if your insomnia worsens or is not better within 7 to 10 days. This may mean that there is another condition causing your sleep problem.

    Be sure that you are able to devote 7 to 8 hours to sleep before being active again. Doxepin should be taken within 30 minutes of bedtime. Do not take with alcohol or with other medicines that can make you sleepy. If you are on a monoamine oxidase inhibitor (MAOI) or have taken a MAOI within the past two weeks, you should not take Doxepin. You should not take Doxepin if you have an eye problem called narrow angle glaucoma that is not being treated, if you have severe urinary retention, or if you are allergic to any of the ingredients in Doxepin. You should not drive or operate machinery at night after taking Doxepin. Until you know how you will react to Doxepin, you should be careful in performing such activities during the day following taking Doxepin. Before you take Doxepin, tell your doctor if you have a history of depression, mental illness or suicidal thoughts. You should call your doctor right away if after taking Doxepin you walk, drive, eat or engage in other activities while asleep. Drowsiness is the most common adverse event observed in clinical trials. For more information, please see the complete Prescribing Information, including the Medication Guide.

    It is not known if Doxepin is safe and effective in children.

    What should I tell my healthcare provider before taking Doxepin?

    Before you take Doxepin, tell your healthcare provider if you:

    • See “Who should not take Doxepin?”
    • Have a history of depression, mental illness, or suicidal thoughts
    • Have severe sleep apnea
    • Have kidney or liver problems
    • Have a history of drug or alcohol abuse or addiction
    • Have a history of glaucoma or urinary retention
    • Have any other medical conditions
    • Are pregnant or plan to become pregnant. It is not known if Doxepin will harm your unborn baby.
    • Talk to your healthcare provider if you are pregnant or plan to become pregnant.
    • Are breast-feeding or plan to breast-feed. Doxepin can pass into your milk and may harm your baby. Talk to your healthcare provider about the best way to feed your baby if you take Doxepin.
    • You should not breast-feed while taking Doxepin.
    • Tell your doctor about all of the medicines you take including prescription and nonprescription medicines, vitamins and herbal supplements.

    Doxepin and other medicines may affect each other causing side effects. Doxepin may affect the way other medicines work, and other medicines may affects how Doxepin works. Especially tell your healthcare provider if you take:

    • A monoamine oxidase inhibitor (MAOI).

    Who should not take Doxepin?

    You should not take Doxepin if you take:

    • Cimetidine (Tagamet) or other medicines that can affect certain liver enzymes.
    • Certain allergy medicines (antihistamines) or other medicines that can make you sleepy or affect your breathing.
    • The diabetes medicine tolazamide.
    • Ask your doctor or pharmacist if you are not sure if your medicine is one that is listed above.

    Know the medicines you take. Keep a list of your medicines with you to show your doctor and pharmacist each time you get a new medicine.

    Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide.

    Do not use Doxepin for a condition for which it was not prescribed. Do not share Doxepin with other people, even if you think they have the same symptoms that you have. It may harm them.

    INDICATIONS

    SILENOR® is indicated for the treatment of insomnia characterized by difficulty with sleep maintenance. The clinical trials performed in support of efficacy were up to 3 months in duration.

    DOSAGE AND ADMINISTRATION

    The dose of SILENOR® should be individualized.

    Dosing In Adults

    The recommended dose of SILENOR® for adults is 6 mg once daily. A 3 mg once daily dose may be appropriate for some patients, if clinically indicated.

    Dosing In The Elderly

    The recommended starting dose of SILENOR® in elderly patients (≥ 65 years old) is 3 mg once daily. The daily dose can be increased to 6 mg, if clinically indicated.

    Administration

    SILENOR® should be taken within 30 minutes of bedtime.

    To minimize the potential for next day effects, SILENOR® should not be taken within 3 hours of a meal.

    The total SILENOR® dose should not exceed 6 mg per day.

    How should I take Doxepin?

    • Take Doxepin exactly as your healthcare provider tells you to take it.
    • Your healthcare provider will tell you how many Doxepin to take and when to take them.
    • Your healthcare provider may change your dose if needed.
    • Take Doxepin within 30 minutes of bedtime. After taking Doxepin, you should confine your activities to those necessary to prepare for bed.
    • Do not take Doxepin within 3 hours of a meal. Doxepin may not work as well, or may make you sleepy the next day if taken with or right after a meal.
    • Do not take Doxepin unless you are able to get a full night of sleep before you must be active again.
    • Call your healthcare provider if your sleep problems get worse or do not get better within 7 to 10 days. This may mean that there is another condition causing your sleep problem.
    • If you take too much Doxepin, call your healthcare provider or get medical help right away.

    What should I avoid while taking Doxepin?

    • You should not drink alcohol while taking Doxepin. Alcohol can increase your chances of getting serious side effects with Doxepin.
    • You should not drive, operate heavy machinery, or do other dangerous activities after Doxepin.
    • You may still feel drowsy the next day after taking Doxepin. Do not drive or do other dangerous activities after taking Doxepin until you feel fully awake.

    What is the most important information I should know about Doxepin?

    • The most common side effect of Doxepin is drowsiness or tiredness.

    Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

    These are not all the possible side effects of Doxepin. For more information ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

    How should I store Doxepin?

    • Store Doxepin between 68° and 77°F (20° to 25°C).
    • Keep Doxepin in a tightly closed container, and away from light. Safely throw away medicine that is out of date or no longer needed.
    • Keep Doxepin and all medicines out of the reach of children.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.