Weight Management
Semaglutide
Weight Management
Semaglutide
Semaglutide – the active ingredient in Wegovy® – is a medication used primarily for the treatment of type 2 diabetes and obesity. It’s a glucagon-like peptide-1 (GLP-1) receptor agonist, which means it mimics the action of the GLP-1 hormone in the body. GLP-1 helps control blood sugar by increasing insulin, reducing blood sugar levels, and slowing digestion.
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Through Rex MD, a licensed healthcare provider can prescribe brand-name semaglutide online, if appropriate. No in-person doctor visit needed. Plus, you’ll get your medication quickly and discreetly with free, overnight shipping.
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How Semaglutide Works
A weekly injection that may promote weight loss
Helps reduce appetite, curb cravings and manage blood sugar
Mimics GLP-1 hormones and may help support healthy weight loss
How to take it
Semaglutide is usually administered via subcutaneous injection (under the skin) once weekly.
Common side effects of semaglutide
Common side effects may include nausea, vomiting, diarrhea, and constipation. More serious but less common side effects can include pancreatitis, kidney problems, and allergic reactions.
Why Semaglutide
(GLP-1)?
GLP-1s are an effective option for weight loss because it helps curb appetite and promotes feelings of fullness. Combined with healthy eating and exercise, it leads to significant weight loss, making it a reliable choice for managing weight.
Get Started NowHow it Helps
Manages blood sugar
Semaglutide may help regulate blood sugar levels by increasing insulin secretion and decreasing glucagon release. This helps improve the body's ability to manage glucose.
Promotes weight loss
Semaglutide may contribute to weight management when combined with a healthy diet and exercise by reducing appetite and increasing feelings of fullness.
Supports overall health
Semaglutide may reduce the risk of obesity-related health conditions like heart disease and type 2 diabetes.
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Dan D.
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Scott S.
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Alan S.
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Dave P.
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John B.
“Love your service and product. Changed everything for the better. THANK YOU !!!”
Chris W.
“There’s always improvements on everything but this service is well organized and I think a lot of customers will be very satisfied like I am.”
Billy I.
“The service was great and the price was affordable.”
Michael G.
“I’ve attempted to use two other sites and they made it exceptionally difficult and drawn out. Your system was quick and efficient.”
Ben T.
“I can’t think of anything else that could be better, this system is perfect.“
Dan D.
“Actually I was skeptical at first. After a painless questionnaire everything worked out great.”
Scott S.
“Everything was perfect. My prescription showed up on time the doctor was easy to talk to - I couldn’t be happier with the product.”
Alan S.
“Keep making your customer service awesome for all customers.”
Dave P.
“Was actually easy for a non computer savvy old man.”
John B.
“Love your service and product. Changed everything for the better. THANK YOU !!!”
Chris W.
“There’s always improvements on everything but this service is well organized and I think a lot of customers will be very satisfied like I am.”
Billy I.
“The service was great and the price was affordable.”
Why choose Rex MD?
Rex MD provides ongoing care from U.S.-licensed clinicians to support your weight loss goals paired with prescription medications like brand-name semaglutide when appropriate. No in-person doctor visit required!
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Ongoing support from our care team
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Access to branded GLP-1 medications
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Fast, free delivery
How to Take Semaglutide
Semaglutide is administered as a weekly subcutaneous injection. Your medication will include specific instructions, but it's essential to follow your healthcare provider's detailed guidance for both dosage and injection technique.
Steps for Getting Treatment
1. Answer questions about your health history and weight loss goals.
Answer questions about your health history and weight loss goals.
2. Personalized review
A licensed physician will work with you to determine which medication, if any, may be most suited to your needs.
3. Fast, discreet shipping
If prescribed, your medication will be processed and shipped overnight in discreet packaging.
4. Ongoing support
Contact our team anytime to discuss your treatment and make adjustments, if needed.
Frequently asked questions about Semaglutide
How do I know if I qualify for semaglutide?
Semaglutide may be prescribed to adults with type 2 diabetes or obesity. It may also be suitable for you if you have a chronic condition that requires weight loss.
If you are prescribed brand-name semaglutide and find that it is not suitable for you, talk to your healthcare provider about other GLP-1s — such as tirzepatide (Zepbound®) or liraglutide (Saxenda®) — that may benefit you.
Rex MD is here to help you reach your weight loss goals in an effective way. Be sure to accurately communicate your medical history with your healthcare provider to determine if semaglutide is a good option.
Note: This medication is not safe for anyone with a personal or family history of thyroid cancer or multiple endocrine neoplasia type 2 (MEN2).
What if I don’t qualify for semaglutide?
If you’re not eligible for a GLP-1 for any reason, Rex MD also offers Triple Therapy – a doctor-trusted treatment plan that combines three oral medications: metformin, bupropion, and topiramate. These are prescribed in carefully selected doses to support weight loss and appetite control.
Triple Therapy is an easy-to-follow daily regimen, typically starting with three pills once a day for the first 30 days. After that, many patients are instructed to take three pills twice daily. Your Rex MD-affiliated provider will guide you through the dosing plan that’s right for you.
Patients often choose Triple Therapy because it’s needle-free, cost-effective, and accessible – even if they don’t qualify for GLP-1 medications like Wegovy®.
Can semaglutide be used with other medications?
Semaglutide can often be used alongside other medications for diabetes or weight management. However, it's crucial to inform your healthcare provider about all medications you are taking to avoid potential interactions.
How long does it take for semaglutide to work?
The effectiveness of semaglutide varies among individuals. Some people may start to see improvements in blood sugar levels or weight loss within a few weeks of starting treatment, while for others, it may take longer.
How long does semaglutide stay in your system?
Semaglutide has a half-life of about one week, meaning it takes approximately seven days for the concentration of the drug in the body to be reduced by half. Given this, semaglutide can stay in your system for about four to five weeks after your last dose. However, the exact duration may vary depending on individual factors such as metabolism, age, kidney function, and overall health.
Is Wegovy® (brand-name semaglutide) safe?
Wegovy® is FDA-approved for chronic weight management and has been studied in multiple clinical trials – but like any prescription medication, it may not be right for everyone.
While many people tolerate Wegovy® well, it can cause side effects like nausea, vomiting, diarrhea, and constipation – especially during dose adjustments. Serious risks are rare but possible, including inflammation of the pancreas, gallbladder issues, or changes in mood. That’s why it’s important to use Wegovy® under the guidance of a healthcare provider who can monitor your response and adjust your treatment if needed.
Wegovy® is not recommended for anyone with a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer), or for people with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). It may also not be appropriate for people with certain gastrointestinal conditions, a history of pancreatitis, or those who are pregnant or planning to become pregnant.
Your Rex MD-affiliated provider will review your medical history, current medications, and overall health to help determine whether Wegovy® is a safe and appropriate option for you.
How much does brand-name semaglutide cost with the Rex MD Weight Management Program?
Brand-name semaglutide is accessible through Rex MD’s Weight Management program, if clinically appropriate. If your Rex MD-affiliated healthcare provider prescribes Wegovy® (semaglutide), it may be available through NovoCare® – a direct-to-patient pharmacy platform affiliated with Novo Nordisk, the manufacturer of Wegovy®.
Eligible patients – such as those who are uninsured or whose commercial insurance doesn't cover Wegovy® – may be able to purchase it via NovoCare® at a cash-pay price of $499 per month (regardless of dosage strength). Your Rex MD-affiliated provider will send your prescription directly to NovoCare®, and you’ll receive instructions to set up your account, complete payment, and arrange delivery.
Pricing and availability are subject to change, so be sure to visit the NovoCare® website for the most up-to-date details.
Is there a generic version of semaglutide available?
No, there isn’t a generic version of semaglutide currently available. Semaglutide is still protected under patent by its manufacturer Novo Nordisk, so the FDA hasn’t approved any true generic equivalents yet.
Compounded semaglutide isn’t the same as a generic version. Compounding a medication means a pharmacy custom-makes a replica of the medication, and this can happen for a number of clinical reasons or during a drug shortage. Pharmacies were allowed to compound semaglutide while there was an official shortage, but the FDA has since declared that the shortage is over. This means pharmacies can no longer compound semaglutide.
Is semaglutide covered by insurance?
The Rex MD GLP-1 Weight Management Program doesn’t accept insurance at this time. Rex MD’s parent company LifeMD accepts insurance for qualifying patients and has access to branded GLP-1 medications like Zepbound®, Wegovy®, and more. For more information about their Weight Management program, visit LifeMD.
GLP-1 receptor agonists—including semaglutide, liraglutide, dulaglutide, and tirzepatide—have been prescribed for weight management, including obesity, along with a reduced caloric diet and increased physical activity. Take precaution with, and read all warnings concerning, GLP-1s, as they may cause serious side effects, including a risk of thyroid c-cell tumors. Do not use if you or your family have a history of a type of thyroid cancer called MTC (medullary thyroid carcinoma) or MEN 2 (multiple endocrine neoplasia syndrome).
