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Premature Ejaculation

Sertraline

Premature Ejaculation

Sertraline

Sertraline (the generic, unbranded version of Zoloft) is a prescription medication that can help you and your partner enjoy longer-lasting sex. More specifically, it’s a selective serotonin reuptake inhibitor (SSRI) that may be prescribed off-label to treat premature ejaculation, or PE.

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Through Rex MD, a licensed healthcare provider can prescribe sertraline online, if appropriate. No in-person doctor visit needed. Plus, you’ll get your medication quickly and discreetly with free, rush shipping.

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Meet Sertraline

Shown in studies to help prevent PE
Taken daily for longer-lasting sex
Available with free, discreet shipping

How to take it

Always take sertraline as instructed by your healthcare provider. Sertraline is taken daily, even if you don’t expect to have sex every day. It should be taken at the same time every day, and can be taken with or without food. If you have trouble sleeping, it's best to take sertraline in the morning.

Common side effects of sertraline

Potential side effects can include fatigue, problems sleeping, reduced appetite, headaches, dizziness, diarrhea, dry mouth, changes in body weight, and erectile dysfunction. Some men take sertraline with a prescription ED medication to prevent sexual side effects.

Prescription products require an online consultation with a physician who will determine if a prescription is appropriate.

ⓘ Important safety information ›

Why
Sertraline?

Sertraline helps balance your serotonin levels, which can help delay ejaculation and lead to longer-lasting sex.

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How It Helps

Helps balance serotonin levels

Sertraline helps block the reabsorption of serotonin into neurons. This makes more serotonin available to improve transmission of messages between neurons.

Delays ejaculation

Balanced serotonin levels can help men control their climax during sex.

Supports sexual performance

When men are able to control their climax and prevent premature ejaculation, they are able to enjoy more satisfying, longer-lasting sex with their partner.

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“Actually I was skeptical at first. After a painless questionnaire everything worked out great.”

Scott S.

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Chris W.

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Michael G.

“I’ve attempted to use two other sites and they made it exceptionally difficult and drawn out. Your system was quick and efficient.”

Ben T.

“I can’t think of anything else that could be better, this system is perfect.“

Dan D.

“Actually I was skeptical at first. After a painless questionnaire everything worked out great.”

Scott S.

“Everything was perfect. My prescription showed up on time the doctor was easy to talk to - I couldn’t be happier with the product.”

Alan S.

“Keep making your customer service awesome for all customers.”

Dave P.

“Was actually easy for a non computer savvy old man.”

John B.

“Love your service and product. Changed everything for the better. THANK YOU !!!”

Chris W.

“There’s always improvements on everything but this service is well organized and I think a lot of customers will be very satisfied like I am.”

Billy I.

“The service was great and the price was affordable.”

Why choose Rex MD?

Rex MD helps eligible patients get prescription medications like sertraline quickly, discreetly, and affordably — right from home. No in-person doctor visit needed.

  • The best price per pill, guaranteed

  • Free online consultation

  • Fast, free, discreet delivery

  • Ongoing support from our care team

How to take sertraline

Always take sertraline as instructed by your healthcare provider. Typically, this medication is taken daily, at the same time each day. It can be taken with or without food. If you have trouble sleeping, it's best to take sertraline in the morning.

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Steps for Getting Treatment

1. Free online consultation

Answering questions about your symptoms and health history.

2. Personalized review

If appropriate a licensed physician will prescribe a treatment plan that meets your needs.

3. Fast, discreet shipping

Your medication will ship out in discreet packaging within two days.

4. Ongoing support

Contact our team anytime to discuss your treatment and make adjustments, if needed.

Frequently asked questions about Sertraline

What is sertraline?

Sertraline is a selective serotonin reuptake inhibitor (SSRI) that can be used to treat premature ejaculation.

What is sertraline used for?

While sertraline (the generic version of Zoloft) is often used to treat depression and other psychological disorders, it may also be prescribed off-label to treat premature ejaculation.

Does sertraline cause weight gain?

In some patients, sertraline may lead to a small weight gain ranging from 1% to 1.6% of initial body weight when it’s used for over six months.

Is sertraline a controlled substance?

No, sertraline is not a controlled substance. It is in an antidepressant drug class known as selective serotonin reuptake inhibitors (SSRIs).

Does sertraline make you sleepy?

You can feel drowsy in the first few days of taking sertraline. This should get better after the first week or two. If it makes you feel drowsy, try taking it just before you go to bed. Strangely, you can also get insomnia while using sertraline. If this is the case, try taking your medication before bed.

Can you overdose on sertraline?

Sertraline and other SSRI medications are considered relatively safe even in overdose. If a patient does overdose on sertraline, it may lead to lethargy, tremors, nausea, vomiting, mydriasis, tachycardia, and other negative effects. Always use sertraline as directed by your provider.

How long does sertraline stay in your system?

Sertraline stays in your system for about five days.

Is sertraline an MAOI?

No. Sertraline is not a monoamine oxidase inhibitor (MAOI). It is in an antidepressant drug class known as selective serotonin reuptake inhibitors (SSRIs).

ⓘ Important safety information ›

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Important Safety Information

Premature Ejaculation
Last Updated: Aug 15, 2024
Table of Contents
  1. Sertraline
 

Disclaimer: Sertraline and other antidepressant medicines may cause serious side effects. Call your healthcare provider right away if you have any of the following symptoms, or call 911 if there is an emergency.

Suicidal thoughts or actions:

  • Sertraline and other antidepressant medicines may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed.
  • Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions.
  • Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe.
    • >
  • Pay particular attention to such changes when sertraline is started or when the dose is changed.
  • Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms.

Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency, especially if they are new, worse, or worry you:

  • attempts to commit suicide
  • acting aggressive or violent
  • new or worse depression
  • feeling agitated, restless, angry or irritable
  • an increase in activity or talking more than what is normal for you
  • acting on dangerous impulses
  • thoughts about suicide or dying
  • new or worse anxiety or panic attacks
  • trouble sleeping
  • other unusual changes in behavior or mood

Serotonin Syndrome

This condition can be life-threatening and symptoms may include:

  • agitation, hallucinations, coma, or other changes in mental status
  • coordination problems or muscle twitching (overactive reflexes)
  • racing heartbeat, high or low blood pressure
  • nausea, vomiting, or diarrhea
  • sweating or fever
  • muscle rigidity

Increased chance of bleeding

Sertraline and other antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAIDs, like ibuprofen or naproxen), or aspirin.

Manic episodes

Symptoms may include:

  • greatly increased energy
  • racing thoughts
  • unusually grand ideas
  • severe trouble sleeping
  • reckless behavior
  • excessive happiness or irritability
  • talking more or faster than usual

Seizures or Convulsions

Glaucoma (angle-closure glaucoma)

Many antidepressant medicines including sertraline may cause a certain type of eye problem called angle-closure glaucoma. Call your healthcare provider if you have eye pain, changes in your vision, or swelling or redness in or around the eye. Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.

Changes in appetite or weight

Children and adolescents should have height and weight monitored during treatment.

Low salt (sodium) levels in the blood

Elderly people may be at greater risk for this. Symptoms may include:

  • Headache
  • weakness or feeling unsteady
  • confusion, problems concentrating or thinking, or memory problems

Do not stop sertraline without first talking to your healthcare provider. Stopping sertraline too quickly may cause serious symptoms including:

  • anxiety, irritability, high or low mood, feeling restless or changes in sleep habits
  • headache, sweating, nausea, dizziness
  • electric shock-like sensations, shaking, confusion

What is sertraline (ZOLOFT)?

Sertraline is a prescription medicine used to treat:

  • Major Depressive Disorder (MDD)
  • Panic Disorder
  • Social Anxiety Disorder
  • Obsessive Compulsive Disorder (OCD)
  • Posttraumatic Stress Disorder (PTSD)
  • Premenstrual Dysphoric Disorder (PMDD)

It is important to talk with your healthcare provider about the risks of treating depression and also the risks of not treating it. You should discuss all treatment choices with your healthcare provider.

Sertraline is safe and effective in treating children with OCD age 6 to 17 years.

It is not known if sertraline is safe and effective for use in children under 6 years of age with OCD or children with other behavior health conditions.

Talk to your healthcare provider if you do not think that your condition is getting better with sertraline treatment.

Who should not take sertraline (ZOLOFT)?

Do not take sertraline if you:

  • take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid.
  • have taken an MAOI within 2 weeks of stopping sertraline unless directed to do so by your healthcare provider.
  • have stopped taking an MAOI in the last 2 weeks unless directed to do so by your healthcare provider.
  • take any other medicines that contain sertraline (such as sertraline HCl or sertraline hydrochloride).
  • take the antipsychotic medicine pimozide (Orap®) because this can cause serious heart problems.
  • are allergic to sertraline or any of the ingredients in sertraline. See the end of this Medication Guide for a complete list of ingredients in sertraline.
  • take Antabuse® (disulfiram) (if you are taking the liquid form of sertraline) due to the alcohol content.

People who take sertraline close in time to an MAOI may have serious or even life-threatening side effects. Get medical help right away if you have any of these symptoms:

  • high fever
  • rapid changes in heart rate or blood pressure
  • uncontrolled muscle spasms
  • confusion
  • stiff muscles
  • loss of consciousness (pass out)

What should I tell my healthcare provider before taking sertraline (ZOLOFT)?

Before starting sertraline, tell your healthcare provider if you have:

  • liver problems
  • heart problems
  • bipolar disorder or mania
  • kidney problems
  • or have had seizures or convulsions
  • a history of a stroke
  • high blood pressure
  • or have had bleeding problems

Are pregnant or plan to become pregnant. Your baby may have withdrawal symptoms after birth or may be at increased risk for a serious lung problem at birth. Talk to your healthcare provider about the benefits and risks of taking sertraline during pregnancy.

Are breastfeeding or plan to breastfeed. A small amount of sertraline may pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking sertraline.

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Sertraline and some medicines may interact with each other, may not work as well, or may cause serious side effects

Your healthcare provider or pharmacist can tell you if it is safe to take sertraline with your other medicines. Do not start or stop any medicine while taking sertraline without talking to your healthcare provider first.

Withholding or providing inaccurate information about your health and medical history in order to obtain treatment may result in harm, including, in some cases, death.

How should I take sertraline (ZOLOFT)?

  • Take sertraline exactly as prescribed. Your healthcare provider may need to change the dose of sertraline until it is the right dose for you.
  • Sertraline Tablets may be taken with or without food.
  • Sertraline Oral Solution may look cloudy or hazy after mixing, this is normal.
  • Sertraline Oral Solution must be diluted before use
  • Do not mix sertraline until you are ready to take it.
  • When diluting sertraline Oral Solution, use only water, ginger ale, lemon/lime soda, lemonade, or orange juice.
  • The oral dropper contains latex. If you are sensitive or allergic to latex, ask your healthcare provider or pharmacist about the best way to measure your medicine.
  • If you miss a dose of sertraline, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of sertraline at the same time

If you take too much sertraline, call your healthcare provider or poison control center right away, or go to the nearest hospital emergency room right away.

What should I avoid while taking sertraline (ZOLOFT)?

Sertraline can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how sertraline affects you. Do not drink alcohol while you take sertraline.

What are the possible side effects of sertraline (ZOLOFT)?

The most common side effects in adults who take sertraline include:

  • nausea, loss of appetite,
  • diarrhea, or indigestion
  • increased sweating
  • tremor or shaking
  • agitation
  • change in sleep habits including increased sleepiness or insomnia
  • sexual problems including decreased libido and ejaculation failure
  • feeling tired or fatigued
  • anxiety

The most common side effects in children and adolescents who take sertraline include abnormal increase in muscle movement or agitation, nose bleeds, urinary incontinence, aggressive reaction, possible slowed growth rate, and weight change. Your child’s height and weight should be monitored during treatment with sertraline.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of sertraline. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

How should I store sertraline?

  • Store sertraline at room temperature, 68°F to 77°F (20°C to 25°C).
  • Keep sertraline bottle closed tightly.

Keep sertraline and all medicines out of the reach of children.

General information about the safe and effective use of sertraline:

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use sertraline for a condition for which it was not prescribed. Do not give sertraline to other people, even if they have the same condition. It may harm them.

This Medication Guide summarizes the most important information about sertraline. If you would like more information, talk with your healthcare provider. You may ask your healthcare provider or pharmacist for information about sertraline that is written for healthcare professionals.

For more information about sertraline call 1-800-438-1985 or go to www.pfizer.com

What are the ingredients in sertraline?

Active ingredient: sertraline hydrochloride

Inactive ingredients: Tablets: dibasic calcium phosphate dihydrate, D&C Yellow #10 aluminum lake (in 25 mg tablet), FD&C Blue #1 aluminum lake (in 25 mg tablet), FD&C Red #40 aluminum lake (in 25 mg tablet), FD&C Blue #2 aluminum lake (in 50 mg tablet), hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, synthetic yellow iron oxide (in 100 mg tablet), and titanium dioxide.

Oral solution: glycerin, alcohol (12%), menthol, butylated hydroxytoluene (BHT)

Popular Questions

Can I use sertraline with alcohol?

  • The PDR states that it is not recommended to drink alcohol while taking sertraline although there is no known interaction between sertraline and alcohol.
  • There is no major drug interaction between sertraline and alcohol. However, the manufacturer of Zoloft (brand name for sertraline) recommends against using sertraline with alcohol.

How is sertraline used to treat PE?

  • Sertraline can be used in two ways to treat P.E. It can be taken daily at a convenient time (e.g. after brushing your teeth in the morning) or it can be taken 4-8 hours before you plan to have sex. Daily use is generally more effective. However, some people may prefer to take a pill only when they plan to have sex instead of daily. For example: people who have sex once or twice a month may not want to take a pill daily. Some people also may just not like the idea of having to take medicine every day.

Is sertraline affected by food?

  • Sertraline can be taken with or without food. Grapefruit juice may increase sertraline levels in the blood by inhibiting the breakdown of sertraline.

Can I get a sertraline prescription online?

  • Yes, you can get a prescription through a quick and easy online visit, if determined appropriate by a network of U.S. licensed physicians.