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Prescription Toenail
Fungus Treatment

Toenail fungus no longer needs to be an issue.

Ciclopirox (generic Penlac®) is a prescription medication clinically proven to treat toenail fungus. Start treatment now by getting prescribed through our online consultation, free rush shipping included.

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Available in all 50 states

* Prescription products require a free online consultation with a clinician who will determine if a prescription is appropriate.

FDA Approved Medication

Free Rush Discreet Delivery

Ongoing Medical Support

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How Does Ciclopirox (generic Penlac®) Compare?

  • Ciclopirox

    Fungix

    Lamisil

    Lotrimin

  • Clinically Proven
  • Prescription Medication
  • Kills Toenail Fungus
  • Diabetic Friendly
  • Easy to Apply
  • Doctor's Choice
  • Get Started Save 50% TODAY
    “My toenail has completely healed & looks wonderful! YAY!!!”

The Reason Your Nails
Are Discolored

  • What is Toenail Fungus?

    Toenail Fungus or Onychomycosis (on-ick-oh-my-CO-sis), a condition that may involve the toenails or fingernails, is relatively common, potentially affecting as many as 35 million people in the US. Toenail fungus is an infection that gets in through cracks in your nail or cuts in your skin. It can make your toenail change color or get thicker. It can also hurt. Because toes are often warm and damp, fungus grows well there. Left untreated, an infection could spread to other toenails, skin, or even your fingernails.

  • What are the symptoms of Toenail Fungus?

    Infected nails are usually thicker than normal and could be warped or oddly shaped. They can break easily. Nails with fungus might look yellow. Sometimes a white dot shows up on the nail and then gets bigger. When fungus builds up under your nail, it can loosen and even separate the nail from the bed. The fungus can also spread to the skin around your nail.

  • Who Gets Toenail Fungus?

    Men are more likely to get it than women. The older you are, the better your chances are, too. People who have diabetes, athlete's foot, or a weak immune system, who smoke, or whose family members have it are also at a higher risk. If you spend a lot of time in the water or you've injured your toenail, your odds for getting toenail fungus go up.

† Ciclopirox may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, severe irritation, redness, burning, blistering, peeling, swelling.

Can Ciclopirox
Treat My Toenail
Issue?

Absolutely. Ciclopirox (generic Penlac®) is a FDA-approved prescription medication that has been clinically proven to treat and even cure toenail fungus. Ciclopirox is in a class of drugs called antifungals, which work by stopping the growth of targeted fungus.

When applied daily, Ciclopirox works by binding to essential co-factors for enzymes in fungus. This negatively affects the fungus’ ability to perform cellular metabolism, properly form cell wall structure and other crucial cell functions. Over time, Ciclopirox works to kill toenail fungus altogether.

Click Here if your’re ready to finally fight back against toenail fungus & discoloration.

How Quickly Does it Start Working
for Toenail Fungus?

Unlike what you find over the counter, Ciclopirox gets to
work immediately. Just wait for new toenail growth.

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Treatment with Ciclopirox

A clinician will evaluate your medical information to determine if Rx treatment is appropriate.
If prescribed, we will ship your treatment in discreet, unmarked packaging.

Toenail Fungus Treatment

Ciclopirox (generic Penlac®) 8% Topical Solution

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The Process

It’s the easiest way to start fighting toenail fungus from the privacy of your home.
If prescribed, we will ship your treatment in discreet, unmarked packaging.

1
Quick Questionnaire

We’ll ask you a couple of quick medical questions. Afterwards, a clinician will review your answers and issue you a prescription, if appropriate.

2
Free Rush Delivery

Your selected medication will be delivered for free in discreet packaging. We’ll also include some helpful info to make sure you get the best out of it.

3
Medical Support

Chat with a medical expert whenever you need. We’ve got your back whenever, on the phone, or via email.

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What’s Next?

If you don’t love the results, we’re here to help. Talk to your Rex MD clinician and they will work with you
to find the best solution for you.

Update treatment

If you don’t see results quick enough, let us know. Your clinician may be able to increase your dose or switch you to a different medication.

If you experience side effects, message your clinician and they’ll determine if another medication or dose is better for you.

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Frequently Asked Questions

  • What is Toenail Fungus?

    Toenail fungus or onychomycosis (on-ick-oh-my-CO-sis), a condition that may involve the toenails or fingernails, is relatively common. It may affect as many as 35 million people in the US — but toenail infections are particularly common.

  • What are the symptoms of Toenail Fungus?

    Symptoms of toenail fungus may include:

    • Thickening of the nail
    • Discoloration
    • Change in nail shape
    • Loosening/lifting of nail
    • Brittleness
    • Crumbling of nail edges
  • What are the risk factors that contribute to Toenail Fungus?

    Factors that can increase the risk of developing toenail fungus include:

    • Wearing closed-toe shoes
    • Getting pedicures with improperly sanitized tools
    • Having a chronic illness, such as diabetes or HIV
    • Having a deformed nail or a nail disease
  • What is Ciclopirox?

    Ciclopirox (generic Penlac®) (sye kloe PEER ox) NAIL SOLUTION is an antifungal medicine. It used to treat fungal infections of the nails.

  • What should I tell my Rex MD clinician before I take this medicine?

    They need to know if you have any of these conditions:

    • diabetes mellitus
    • history of seizures
    • HIV infection
    • immune system problems or organ transplant
    • large areas of burned or damaged skin
    • peripheral vascular disease or poor circulation
    • taking corticosteroid medication (including steroid inhalers, cream, or lotion)
    • an unusual or allergic reaction to ciclopirox, isopropyl alcohol, other medicines, foods, dyes, or preservatives
  • What should I watch for?

    Tell your doctor or health care professional if your symptoms get worse. Four to six months of treatment may be needed for the nail(s) to improve. Some people may not achieve a complete cure or clearing of the nails by this time.

    Tell your doctor or health care professional if you develop sores or blisters that do not heal properly. If your nail infection returns after stopping using this product, contact your doctor or health care professional.

  • Are there any side effects?

    Side effects with ciclopirox are rare, but can occur.
    Side effects that you should report to your doctor or health care professional as soon as possible:

    allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue severe irritation, redness, burning, blistering, peeling, swelling, oozing Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

    mild reddening of the skin nail discoloration temporary burning or mild stinging at the site of application What may interact with this drug? Interactions are not expected. Do not use any other skin products without telling your doctor or health care professional.

  • How should I use this drug?

    This medicine is for external use only. Follow the directions that come with this medicine exactly. Wash and dry your hands before use. Avoid contact with the eyes, mouth or nose. If you do get this medicine in your eyes, rinse out with plenty of cool tap water. Contact your doctor or health care professional if eye irritation occurs. Use at regular intervals. Do not use your medicine more often than directed. Finish the full course prescribed by your doctor or health care professional even if you think you are better. Do not stop using except on your doctor's advice.

    Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for children as young as 12 years for selected conditions, precautions do apply.

  • What if I miss a dose?

    If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

  • Where should I store this drug?

    Keep out of the reach of children.

    Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Protect from light by storing the bottle in the carton after every use. This medicine is flammable. Keep away from heat and flame. Throw away any unused medicine after the expiration date.

Important Safety Information Ciclopirox

What Should You Know Before Taking Ciclopirox

Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.

What is ciclopirox?

Ciclopirox is an antifungal medicine that prevents fungus from growing on your skin.

Ciclopirox nail lacquer is used to treat fungal infections of the toenails and fingernails.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use ciclopirox if you are allergic to it.

To make sure ciclopirox topical is safe for you, tell your doctor if you have: diabetes; epilepsy or other seizure disorder; a weak immune system (caused by disease or by using certain medicines); or a condition for which you use steroid medication (including skin conditions or breathing disorders).

Ciclopirox topical is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether ciclopirox topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not use ciclopirox topical on a child without medical advice. Ciclopirox nail lacquer is not approved for use by anyone younger than 12 years old.

To use ciclopirox nail lacquer:

Use on the nails and immediately surrounding skin only. Avoid contact with other areas. Remove any loose nail or nail material using nail clippers or a nail file.

Apply ciclopirox nail lacquer once daily (preferably at bedtime) to all affected nails with the applicator brush provided. Apply the lacquer evenly over the entire nail. Where possible, apply the nail lacquer to the underside of the nail and to the skin beneath it. Allow the lacquer to dry (approximately 30 seconds) before putting on socks or stockings. After applying the medication, wait 8 hours before taking a bath or shower.

Apply ciclopirox nail lacquer daily over the previous coat. Once a week, remove the nail lacquer with alcohol. Remove as much as possible of the damaged nail using nail clippers or nail a file.

To prevent the screw cap from sticking to the bottle, do not allow the solution to get into the bottle treads. To prevent the solution from drying out, close the bottle tightly after every use.

Treatment with ciclopirox nail lacquer may require several months before initial improvement of symptoms is noticed. Up to 48 weeks of daily application of the nail lacquer, monthly removal of the unattached infected nail by a health care professional, and weekly trimming by the patient may be required for complete treatment.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antifungal medicine.

Store all forms of this medicine at room temperature away from moisture, heat, and light. Once a bottle of ciclopirox shampoo is opened, it should be used within 8 weeks.

Ciclopirox nail lacquer is flammable. Avoid using near open flame, and do not smoke until the gel has completely dried on your skin.

Ciclopirox nail lacquer is flammable. Avoid using near open flame, and do not smoke until the gel has completely dried on your skin.

  • • The effectiveness and safety of Ciclopirox Topical Solution, 8%, in the following populations has not been studied. The clinical trials with use of Ciclopirox Topical Solution, 8%, excluded patients who: were pregnant or nursing, planned to become pregnant, had a history of immunosuppression (e.g., extensive, persistent, or unusual distribution of dermatomycoses, extensive seborrheic dermatitis, recent or recurring herpes zoster, or persistent herpes simplex), were HIV seropositive, received organ transplant, required medication to control epilepsy, were insulin dependent diabetics or had diabetic neuropathy. Patients with severe plantar (moccasin) tinea pedis were also excluded.
  • • The safety and efficacy of using Ciclopirox Topical Solution, 8%, daily for greater than 48 weeks have not been established.
CONTRAINDICATIONS

Ciclopirox Topical Solution, 8%, is contraindicated in individuals who have shown hypersensitivity to any of its components.

WARNINGS

Ciclopirox Topical Solution, 8%, is not for ophthalmic, oral, or intravaginal use. For use on nails and immediately adjacent skin only.

PRECAUTIONS

If a reaction suggesting sensitivity or chemical irritation should occur with the use of Ciclopirox Topical Solution, 8%, treatment should be discontinued and appropriate therapy instituted.

So far there is no relevant clinical experience with patients with insulin dependent diabetes or who have diabetic neuropathy. The risk of removal of the unattached, infected nail, by the health care professional and trimming by the patient should be carefully considered before prescribing to patients with a history of insulin dependent diabetes mellitus or diabetic neuropathy.

Information for Patients
  • 1. Use Ciclopirox Topical Solution, 8%, as directed by a health care professional. Avoid contact with the eyes and mucous membranes. Contact with skin other than skin immediately surrounding the treated nail(s) should be avoided. Ciclopirox Topical Solution, 8%, is for external use only.
  • 2. Ciclopirox Topical Solution, 8%, should be applied evenly over the entire nail plate and 5 mm of surrounding skin. If possible, Ciclopirox Topical Solution, 8%, should be applied to the nail bed, hyponychium, and the under surface of the nail plate when it is free of the nail bed (e.g., onycholysis). Contact with the surrounding skin may produce mild, transient irritation (redness).
  • 3. Removal of the unattached, infected nail, as frequently as monthly, by a health care professional is needed with use of this medication. Inform a health care professional if they have diabetes or problems with numbness in your toes or fingers for consideration of the appropriate nail management program.
  • 4. Inform a health care professional if the area of application shows signs of increased irritation (redness, itching, burning, blistering, swelling, oozing).
  • 5. Up to 48 weeks of daily applications with Ciclopirox Topical Solution, 8%, and professional removal of the unattached, infected nail, as frequently as monthly, are considered the full treatment needed to achieve a clear or almost clear nail (defined as 10% or less residual nail involvement).
  • 6. Six months of therapy with professional removal of the unattached, infected nail may be required before initial improvement of symptoms is noticed.
  • 7. A completely clear nail may not be achieved with use of this medication. In clinical studies less than 12% of patients were able to achieve either a completely clear or almost clear toenail.
  • 8. Do not use the medication for any disorder other than that for which it is prescribed.
  • 9. Do not use nail polish or other nail cosmetic products on the treated nails.
  • 10. Avoid use near heat or open flame, because product is flammable.
DOSAGE AND ADMINISTRATION

Ciclopirox Topical Solution, 8%, should be used as a component of a comprehensive management program for onychomycosis. Removal of the unattached, infected nail, as frequently as monthly, by a health care professional, weekly trimming by the patient, and daily application of the medication are all integral parts of this therapy. Careful consideration of the appropriate nail management program should be given to patients with diabetes.

Nail Care By Patient:

Patients should file away (with emery board) loose nail material and trim nails, as required, or as directed by the health care professional, every seven days after Ciclopirox Topical Solution, 8%, is removed with alcohol. Ciclopirox Topical Solution, 8%, should be applied once daily (preferably at bedtime or eight hours before washing) to all affected nails with the applicator brush provided. The Ciclopirox Topical Solution, 8%, should be applied evenly over the entire nail plate.

If possible, Ciclopirox Topical Solution, 8%, should be applied to the nail bed, hyponychium, and the under surface of the nail plate when it is free of the nail bed (e.g., onycholysis).

The Ciclopirox Topical Solution, 8%, should not be removed on a daily basis. Daily applications should be made over the previous coat and removed with alcohol every seven days. This cycle should be repeated throughout the duration of therapy.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of ciclopirox topical is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using ciclopirox topical?

Avoid contact with the eyes, nose, and inside of the mouth. If this does happen, rinse with water.

Avoid using other medications on the areas you treat with ciclopirox topical unless your doctor tells you to.

Do not use nail polish, artificial nails, or other cosmetic nail products on the nails treated with ciclopirox nail lacquer.

Avoid wearing tight-fitting, synthetic clothing that doesn't allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed.

Ciclopirox topical side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using ciclopirox topical and call your doctor at once if you have: unusual or severe itching, redness, burning, dryness, or irritation of treated skin; or discoloration or other changes in the nails.

Common side effects may include:mild burning, itching, or redness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Protect from light (e.g., store the bottle in the carton after every use).
Ciclopirox Topical Solution, 8%, should be stored at room temperature between 59° and 86° F (15° and 30° C).
CAUTION: Flammable. Keep away from heat and flame.

If you are experiencing a medical emergency, call 911 or seek immediate medical attention.

You are encouraged to report negative side effects of prescription products to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see the full Prescribing Information for complete safety information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/21022s004lbl.pdf
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